Autism stem cell treatment in usa4/28/2023 While progress has been made in establishing a psychological and symptom adapted treatment, the search for biologic diagnostic parameters of the disease has become a major topic in recent ASD research. The disease shows an increase in incidence with climbing numbers up to one out of 54 children ( 3). However, causative treatment options are still not available. The genetic background of ASD comprises heterogenic traits ( 2) that are described to be responsible for affecting the brain network signal conduction. Despite the fact that infantile autism has been first described by Leo Kanner ( 1) as early as 1943, yet the etiology of ASD is not completely understood. Treating and raising children with ASD poses an enormous burden. Our results in this small group are encouraging, but certainly need further investigation in larger cohorts. It is postulated that SCT may, among others, assert its positive effect by counteracting a cerebral inflammatory autoimmune process which in turn supports the responsiveness to behavioral and pharmacological interventions. The SCT procedure, in trained hands, can be a safe and promising treatment option in children with ASD, responding in a non-satisfactory manner to conventional treatments. Disappearance of symptoms were observed by the parents during the following year and consequently improved Autism Treatment Evaluation Checklist (ATEC) scores were reported. ![]() At ages of 4–14 years the children received their SCT, no immediate or late adverse events were reported. The decision to perform the procedure was preceded by limited beneficiary impact of conventional symptom-based, psychological and pharmacological interventions. The three boys and one girl received the diagnosis at ages between 2–4 years. ![]() We herein report data of four children diagnosed with ASD, who were treated with autologous, bone marrow (BM)-derived, intrathecally and simultaneously intravenously applied, point-of-care stem cell transplant (SCT). Recently, biological cell therapies involving pluripotent cells have raised hopes towards sustained beneficial outcome.
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